94 Results for "

Astragalus lentiginosus Douglas ex Hook.

" in MedChemExpress (MCE) Product Catalog:
Products (94)

94 Results for "Astragalus lentiginosus Douglas ex Hook." in MCE Product Catalog:

42
42 Publications Verification
Art. -Nr.: HY-N0431
CAS. Nr.: 84687-43-4
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
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6
6 Cited Publications
Art. -Nr.: HY-N0590
CAS. Nr.: 630-94-4
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
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4
4 Cited Publications
Art. -Nr.: HY-32736
CAS. Nr.: 38647-11-9
Synonyms: NSC 165677; PG 492
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
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3
3 Cited Publications
Art. -Nr.: HY-N1353
CAS. Nr.: 569-92-6
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
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3
3 Cited Publications
Art. -Nr.: HY-N0901
CAS. Nr.: 6877-32-3
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
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2
2 Cited Publications
Art. -Nr.: HY-N0434
CAS. Nr.: 84687-42-3
Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .
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2
2 Cited Publications
Art. -Nr.: HY-N2473
CAS. Nr.: 94367-42-7
Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
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2
2 Cited Publications
Art. -Nr.: HY-N0887
CAS. Nr.: 84676-88-0
Synonyms: Isoastragaloside-I
Isoastragaloside I is a natural compound found in Astragalus membranaceus, with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt, NF-κB, MAPKs and PI3K, enhances the activity of hepatic FXR, regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2. Isoastragaloside I inhibits the expression of NO, TNF-α, iNOS, COX-2, IL-1β and VCAM-1, and reduces intracellular ROS levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes .
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1
1 Cited Publications
Art. -Nr.: HY-N0433
CAS. Nr.: 84676-89-1
Synonyms: Astrasieversianin VIII
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
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1
1 Cited Publications
Art. -Nr.: HY-N2411
CAS. Nr.: 60314-89-8
Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
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Art. -Nr.: HY-N0432
CAS. Nr.: 84680-75-1
Synonyms: Astrasieversianin IV; Cyclosieversioside B
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the Wnt/β-catenin signaling pathway .
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Art. -Nr.: HY-159066
Reinheit:  70.29%
Polysachoride of astragalus mongholicus is an astragalus polysaccharide that can be isolated from Astragalus Mongholicus, exhibits antifibrotic activity .
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Art. -Nr.: HY-N5037
CAS. Nr.: 109008-27-7
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
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Art. -Nr.: HY-N0431R
CAS. Nr.: 84687-43-4
Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
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Art. -Nr.: HY-N0424
CAS. Nr.: 84605-18-5
Synonyms: Cyclogalegigenin
Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol.
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Art. -Nr.: HY-W250121
CAS. Nr.: 9000-65-1
Tragacanth gum is an orally active anionic composite polysaccharide and multifunctional biomaterial. Tragacanth gum exhibits biocompatibility, mucoadhesion and renoprotective effects, and effectively promotes wound closure and tissue healing. Tragacanth gum can be isolated from Astragalus gummifer. Tragacanth gum acts as an emulsifier and drug delivery carrier, and is also widely used in fields such as 3D scaffolds, tissue engineering and green nanoparticle preparation. High doses of Tragacanth gum may induce reversible forestomach squamous epithelial hyperplasia in mice, but show no mutagenic or carcinogenic activity. Tragacanth gum is commonly used in studies related to diseases including systemic candidiasis, rheumatoid arthritis and osteosarcoma .
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Art. -Nr.: HY-N0476
CAS. Nr.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
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Art. -Nr.: HY-N4005
CAS. Nr.: 54081-48-0
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .
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Art. -Nr.: HY-161108
CAS. Nr.: 2597167-34-3
Forschungsgebiete:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
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Art. -Nr.: HY-N0888
CAS. Nr.: 86764-11-6
Synonyms: Astrasieversianin-VII
Isoastragaloside II is an astragaloside, which is isolated from the hairy root culture of Astragalus membranaceus.
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